相关实验视频
Updated: Jul 29, 2026

16:19
High Throughput Single-cell and Multiple-cell Micro-encapsulation
Published on: June 15, 2012
18.6K
使用藻状物构建一个高容量的药物微载体
Houjie Wang1, Runyu You1, Yangqi Jin1
1School of Life Sciences, Key Laboratory of the Coastal and Wetland Ecosystems (Xiamen University), Ministry of Education, Xiamen Key Laboratory of Plant Genetics, Xiamen University, Xiamen 361102, China.
Colloids and surfaces. B, Biointerfaces
|January 1, 2025
概括
研究人员开发了一种高容量的药物输送系统,使用涂有酸盐的藻. 这种新型的微载体显著提高了印梅他辛的药物加载效率,并显示了癌症治疗的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 纳米技术纳米技术
背景情况:
- 药物装载能力对于有效的药物输送至关重要,但在以藻 (DF) 为基础的系统中提高药物装载能力是具有挑战性的.
- diatom frustules 为微载体的发展提供了一个有希望的,生物相容的支架.
研究的目的:
- 开发一种高效的药物装载微载体,使用藻 (DF).
- 为了提高药物负载能力和控制印梅他辛 (IND) 的释放概况.
主要方法:
- 使用了来自Thalassiosira weissflogii的藻,经过APTES (DF-NH2) 修改.
- 采用了蒸发式加载方法,并与酸盐 (Chi) 涂层相结合.
- 优化了药物与载体的比率和中等pH值,以获得最大的负载效率.
主要成果:
- 达到高药物加载效率为58.78±1.92%的印度美他辛 (IND).
- 从DF-NH2/IND@Chi微载体中证明了依赖pH的持续药物释放.
- 观察到显著的体外细胞毒性对结肠癌细胞.
结论:
- 蒸发式装载,酸盐涂层和优化条件的组合显著提高了基于DF的载体中的药物装载能力.
- 开发的微载体表现出卓越的性能,超过了之前的报道,并显示出治疗潜力.
- 这种系统的方法提供了一个可行的策略,用于创建使用藻 frustules 先进的药物输送系统.
相关概念视频
Bioavailability Enhancement: Drug Permeability Enhancement
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Production of Pharmaceuticals
Industrial insulin production uses genetically engineered E. coli expressing a proinsulin gene controlled by a tryptophan promoter and containing a methionine linker for later cleavage. The cells also carry ampicillin resistance for selective growth. Seed cultures are stored at −80 °C and production begins by thawing a small amount to inoculate starter cultures, which are progressively scaled to a 50,000-L bioreactor. In the bioreactor, E. coli grow in nutrient-rich media under sterile, tightly...

