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Updated: Jun 4, 2025

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model
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发育动力学模仿逆向工程的周细胞基质为关节软骨再生的发育动力学

Yongkang Yang1, Ziheng Xu1, Songlin He2

  • 1School of Medicine, Nankai University, Tianjin, 300071, PR China; Institute of Orthopedics, The First Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing, 100853, PR China.

Biomaterials
|January 1, 2025
PubMed
概括

这项研究开发了一种新型的支架系统,模仿自然细胞周基质矩阵 (PCM),以改善关节软骨 (AC) 再生的介质干细胞 (MSC) 疗法,增强细胞功能和修复结果.

关键词:
全原子分子动力学模拟所有原子的模拟.软骨的发育动态 软骨的发育动态一层一层的单细胞封装.机械转导是指机械转导的过程.周细胞矩阵是一个周细胞矩阵.

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Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
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