内分泌向治疗改变了乳腺微生物组,以减少雌激素受体α乳腺癌风险
Alana A Arnone1, Yu-Ting Tsai2, J Mark Cline3
1Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA; Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA.
Cell reports. Medicine
|January 1, 2025
概括
内分泌疗法,如他莫西芬修改乳腺微生物组,增加有益的细菌,并可能降低乳腺癌的风险. 益生菌干预也显示出减少瘤生长和扩散的前景.
科学领域:
- 微生物学 微生物学
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
背景情况:
- 乳腺组织的微生物组是可以修改的.
- 内分泌向治疗可能会影响这种微生物群.
研究的目的:
- 研究内分泌疗法,特别是他莫西芬如何重塑非癌症乳腺微生物组.
- 确定这些微生物组改变对组织代谢和乳腺瘤发生的影响.
主要方法:
- 16S rRNA测序以分析微生物社区组成.
- 免疫组织化学检测乳腺组织中的细菌成分.
- 在体内研究,使用与益生菌干预的小鼠模型.
- 在癌细胞上使用益生菌调节介质的体外研究.
主要成果:
- 塔莫西芬改变了小鼠和非人类灵长类动物的乳腺中的微生物β-多样性,并增加了Firmicutes,包括Lactobacillus spp.
- 脂铁醇酸 (LTA) 阳性细菌在接受他莫西芬治疗的乳腺组织中增加.
- 对小鼠的益生菌注射减少了瘤发生,改变了代谢基因表达,减少了瘤增殖.
- 益生菌受条件介质降低了雌激素受体阳性 (ER +) 乳腺癌细胞的活力,并在非癌细胞中改变了线粒体代谢.
- 人类瘤样本显示LTA阳性细菌和Ki67之间存在负相关性,表明增殖减少.
结论:
- 内分泌向治疗改变了乳腺微生物组的组成.
- 这些修改与组织代谢的变化相关,可能降低ER+乳腺癌风险.
- 乳腺微生物组代表了乳腺癌预防和治疗的潜在治疗点.
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