保存比率损伤螺旋计的流行,危险因素和结果:系统性审查和元分析
Nicole M Robertson1, Connor S Centner2, Vickram Tejwani3
1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; Center for Global Non-Communicable Disease Research and Training, School of Medicine, Johns Hopkins University, Baltimore, MD.
Chest
|January 1, 2025
概括
保存比率受损螺旋计 (PRISm) 影响全球12%,增加死亡风险. 针对糖尿病等可修改的风险因素可能会减少PRISm负担和进展到阻塞性肺病.
科学领域:
- 肺部医学 肺部医学
- 流行病学 流行病学
- 全球健康 全球健康
背景情况:
- 慢性呼吸道疾病是一个日益严重的全球健康问题.
- 保留比率受损螺旋计 (PRISm) 与增加的发病率和死亡率有关.
- 描述PRISM仍然是一个存在知识差距的领域.
研究的目的:
- 为了确定PRISm的全球流行情况.
- 为了确定与PRISm相关的风险因素.
- 调查与PRISm相关的临床结果,包括死亡率.
主要方法:
- 一个系统的审查和流行病学研究的元分析.
- 在多个主要数据库中进行的搜索,没有语言或日期限制.
- 使用有效公共卫生实践项目工具对包括的研究进行质量评估.
主要成果:
- 聚合PRISM的流行率为12%,在低收入和中等收入国家 (LMICs) 更高.
- 伴随性糖尿病是显著的风险因素;性别和吸烟数据是混合的.
- PRISm与所有原因,心血管和呼吸道死亡率的增加有关.
结论:
- 患有PRISM的个体面临所有原因,心血管和呼吸道死亡的风险增加.
- 解决PRISM可修改的风险因素可以减轻其全球负担.
- 对LMIC的进一步研究对于了解特定暴露和疾病轨迹至关重要.
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