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在Wistar大鼠中L-mimosine的产前毒性

Elaine R M de Almeida¹, Silvana L Górniak¹, Cláudia Momo¹

¹Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, S.P., Brazil.

Toxicon : official journal of the International Society on Toxinology

|January 1, 2025

概括

来自 Leucaena leucocephala 的 L-Mimosine 穿过胎盘,在老鼠中引起显著的胚胎/胎儿毒性和发育问题. 怀孕期间的暴露对围产期生长和发育构成风险.

科学领域:

毒理学毒理学毒理学
发展生物学发展生物学
药理学药理学是指药理学的学科.

背景情况:

一种植物性化合物L-Mimosine具有金属化特性.
它与代谢通路的相互作用表明了药理学潜力,但也有毒性问题.

研究的目的:

为了研究L-mimosine的体外通道.
评估L-mimosine暴露对Wistar大鼠胚胎发育的影响.

主要方法:

怀孕的Wistar大鼠从6-19号妊娠日开始接受不同剂量的L-mimosine (60-240毫克/公斤).
通过检测羊水中的L-mimosine来评估胎盘过渡.
评估的参数包括母亲的体重,消费,生物化学,血液学,生殖指数和胎儿分析 (骨,内脏,组织病理学).

主要成果:

在暴露于60,100和140毫克/公斤L-mimosine的胎儿身上观察到骨发育的改变.
服用240毫克/千克的组显示食物消耗减少,白细胞/中性粒细胞数量改变,ALT,GGT和肌素水平异常.
高剂量组的重要发现包括胸腺缩,脏变化,骨/内脏形和脱毛;L-mimosine在羊水中被检测到.

结论:

利米素很容易穿过胎盘,对母体和胎儿产生剂量依赖的有毒作用.
周产期暴露于L-mimosine会对胚胎/胎儿和新生儿的生长和发育产生负面影响.
这些发现强调了与怀孕期间接触L-mimosine相关的风险.

关键词:

胎儿的发育胎儿的发育免疫抑制是一种免疫抑制.缺陷形态缺陷形态是一个错误的形态.植物毒素是一种植物毒素.有毒植物有毒植物这种物质是有毒的,有毒的.

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