按需释放胰岛素使用基于基托的三隔间微球,对葡萄糖有反应
Yixin Cai1, Louqian Zhang2, Weixia Cheng3
1Joint Laboratory of Advanced Biomedical Materials (NFU-UGent), Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
International journal of biological macromolecules
|January 1, 2025
概括
研究人员开发了基于酸盐的新型三微球 (TCM),用于按需释放胰岛素. 这些微球通过在血糖水平上升的基础上释放胰岛素来改善糖尿病的葡萄糖控制.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 内分泌学 在内分泌学.
背景情况:
- 可注射的葡萄糖反应性胰岛素输送系统旨在在24小时内持续释放胰岛素.
- 实现按需胰岛素释放仍然是一个关键的挑战,这取决于输送车辆的降解率.
研究的目的:
- 用于制造基于酸盐的三隔间微球 (TCM),用于按需释放胰岛素.
- 为了研究基托的pH反应性降解及其与胰岛素释放动态的相关性.
- 在2型糖尿病模型中评估TCM在调节血糖水平方面的有效性.
主要方法:
- 基于酸盐的TCM是使用气体剪切微流体制造的.
- 使用渐变的奇托桑度来创建不同的pH响应区.
- 胰岛素被封装在每个隔间的不同度.
- 在体外研究中评估了胰岛素释放概况和生物相容性.
- 在化学诱导的2型糖尿病细胞模型中测试了体内疗效.
主要成果:
- 经过TCM检测,可以证明受控的,按需释放的胰岛素是由葡萄糖诱导的pH值变化引发的.
- 胰岛素释放区的数量随着血糖水平的上升而增加.
- 与单个隔间微球相比,TCM表现出增强的结构完整性和延长的药物作用.
- 通过体外实验证实了出色的生物相容性.
- 在2型糖尿病模型中实现了长期血糖调节 (20-35小时).
结论:
- TCM代表了按需胰岛素输送的新方法,利用多隔间设计来实现精确的葡萄糖响应.
- 梯度pH反应和可变的胰岛素负载使得可定制的葡萄糖管理成为可能.
- 这种创新的微球系统具有很大的潜力,可以促进胰岛素类似物和糖尿病治疗方法的发展.
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