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Updated: Jun 4, 2025

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
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专门针对TNFR1的迷你绑定蛋白的设计

Jun Weng1, Miaomiao Geng2, Xiaoyu Hu2

  • 1State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei 430062, China; National & Local Joint Engineering Research Center of High-throughput Drug Screening Technology, School of Life Sciences, Hubei University, Wuhan, Hubei 430062, China; Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.

International journal of biological macromolecules
|January 1, 2025
PubMed
概括

针对TNFR1的新型迷你绑定蛋白为自身免疫性疾病的TNFα抑制剂提供了有希望的替代品,可能减少副作用. 一种迷你绑定剂S1B2在阻断TNFα信号传递方面具有很高的功效.

关键词:
迷你包装机 迷你包装机蛋白质 de novo 设计这就是TNFR1的特点.

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