在非阻塞性亚子精子症的男性中,经过微剖析丸精子提取后的短期荷尔蒙变化:来自大型纵向前多中心研究的结果
Fausto Negri1,2, Edoardo Pozzi1,2,3, Christian Corsini1,2
1Vita-Salute San Raffaele University, Milan, Italy.
The world journal of men's health
|January 1, 2025
概括
在非阻塞性亚精子症 (NOA) 的男性中,微剖析丸精子提取 (mTESE) 并没有显著改变短期激素水平. 然而,一些男性可能会在手术后出现缺乏症 (TD),特别是那些丸体积较小或心脏类型异常的男性.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 安德罗学与人类学
背景情况:
- 非阻塞性精症 (NOA) 影响男性生育能力,微切割丸精子提取 (mTESE) 是一个关键的手术干预.
- 荷尔蒙特征对男性生殖健康至关重要,并且可以受到丸手术的影响.
- 了解mTESE对荷尔蒙水平的影响对于患者的管理和咨询至关重要.
研究的目的:
- 在被诊断为非阻塞性精子缺血症 (NOA) 的男性中,对微切割丸精子提取 (mTESE) 后潜在的荷尔蒙变化进行调查.
- 在接受mTESE的NOA患者中识别激素变化的预测因素,特别是缺乏症 (TD).
主要方法:
- 对接受mTESE的102名NOA男性进行前性分析,不包括先前接受过激素治疗的男性.
- 测量了手术前和手术后3个月的血清激素水平 (总,LH,FSH,17β-雌激素).
- 患者根据手术前和手术后的总 (tT) 水平进行分类,以评估eugonadal状态或TD的发展.
主要成果:
- 与基线相比,mTESE没有显著改变总 (tT),黄素激素 (LH) 或卵泡刺激激素 (FSH) 的短期术后水平.
- 值得注意的是,在mTESE后的3个月内,13.5%的最初是eugonadal的男性出现了缺乏症 (TD).
- 手术后患有TD的男性的丸体积在基线显著降低,型异常的患病率更高.
结论:
- 微切割丸精子提取 (mTESE) 在患有非阻塞性精子缺血症 (NOA) 的男性中不会引起显著的短期激素乱.
- 一部分NOA患者在mTESE后可能出现缺乏症 (TD),这凸显了需要仔细监测荷尔蒙的必要性.
- 下丸体积和型异常与mTESE后发展TD的风险增加有关.
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