上转换的微表显示体内光力动态
Jason R Casar1, Claire A McLellan2, Cindy Shi2
1Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA. jcasar@stanford.edu.
Nature
|January 1, 2025
概括
研究人员开发了可吞的光学微表来测量体内的力量. 这些传感器量化了Caenorhabditis elegans圆的食力,显示了大约10μN的咬力.
科学领域:
- 生物医学工程
- 纳米技术
- 生理学
背景情况:
- 肌肉的动作潜力驱动着体内结构的生理过程.
- 目前的非侵入性技术很难测量这些内部结构的力量.
- 开发新的工具对于了解光器官功能至关重要.
研究的目的:
- 引入新的,无毒的可摄入机械传感器来研究光力.
- 使用这些传感器量化评估活体C. elegans的养力.
- 探索这些传感器在更广泛的生理研究中的潜力.
主要方法:
- 在聚烯微球中使用上转化纳米粒子 (NaY0.8Yb0.18Er0.02F4@NaYF4) 制造光学"微仪".
- 使用光学和原子力显微镜进行体外鉴定,以确定力响应关系.
- 在C. elegans体内应用,结合光成像和非侵入性电生理学.
主要成果:
- 显微仪表表现出线性,无歇斯底里反应,改变发射的红光与绿光的比率.
- 成人C. elegans产生大约10μN的食咬力.
- 测量到的咬力与肌肉活动一致,并与能够溶解细菌食物的应力相对应.
结论:
- 可吞的光学微表提供了一种新的,非侵入性的方法来量化光器官中的力量.
- 这项技术可以详细研究C. elegans的养机制.
- 在各种生理条件和疾病中研究神经肌肉应力具有潜力.
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