卵巢功能测量在normogonadotropic无排卵和亚临床甲状腺功能障碍:一个前性队列研究
Iwona Gawron1, Rafal Baran2, Robert Jach2
1Jagiellonian University Medical College, Faculty of Medicine, Chair of Gynecology and Obstetrics, Kopernika 23, 31-501, Krakow, Poland. iwona.gawron@uj.edu.pl.
Endocrine
|January 1, 2025
概括
亚临床甲状腺功能低下症 (SCH) 和甲状腺自身免疫性 (TAI) 在无排卵的妇女中没有显著影响卵巢功能. 需要进一步的研究来确认甲状腺素补充剂对月经不规则和产科结果的益处.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 甲状腺学 甲状腺学
- 不孕症研究 不孕症研究
背景情况:
- 亚临床甲状腺功能低下症 (SCH) 和甲状腺自身免疫性 (TAI) 是常见的内分泌疾病.
- 它们对卵巢功能的影响,在妇女与正常雌激素无排卵,特别是那些有多囊性卵巢综合征 (PCOS) 或下丘脑-垂体-卵巢功能障碍 (HPOD),需要澄清.
研究的目的:
- 为了比较卵巢功能标志物在euthyroid妇女与normogonadotropic无排卵经历SCH或TAI与那些没有甲状腺功能障碍.
- 为了研究PCOS和HPOD研究臂的潜在差异.
主要方法:
- 一项前性队列研究评估了抗穆勒尔激素 (AMH),FSH,LH,雌激素,,卵巢体积和多囊性卵巢形态 (PCOM).
- 参与者被分为PCOS和HPOD组,根据SCH和TAI状态分为子组.
主要成果:
- 在有和没有SCH或TAI的女性之间,没有发现卵巢功能参数的显著差异.
- 特别的相关性被注意到:TGAb与FSH和在PCOS中,TPOAb与FSH在HPOD中.
- 现型D PCOS与SCH显示左卵巢体积和病变增加;没有TAI的现型A PCOS具有更高的LH.
结论:
- 亚临床甲状腺功能低下症 (SCH) 对卵巢功能指标没有显著临床影响.
- 甲状腺自身免疫 (TAI) 与FSH有相关性,但临床意义尚不确定.
- 目前缺乏证据支持为这些疾病的月经不规则或产科结果补充甲状腺素.
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