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Updated: Jun 4, 2025

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开发具有纳米分子活性的/利氨基酸合物用于向光动力学疗法:设计,合成,SAR和生物评估

Lubov V Krylova1, Vasilii F Otvagin1, Galina P Gribova1

  • 1Lobachevsky State University of Nizhny Novgorod, Gagarina av. 23, Nizhny Novgorod 603950, Russian Federation.

Journal of medicinal chemistry
|January 2, 2025
PubMed
概括

针对表皮生长因子受体 (EGFR) 的新型含联体显示出强大的光动力疗法对抗癌细胞的影响. 这种方法证明了有效的瘤抑制和潜在临床用途的有利安全概况.

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Aryldiazonium Salts to Azo Dyes: Diazo Coupling01:11

Aryldiazonium Salts to Azo Dyes: Diazo Coupling

The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the...
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