在老年高血压患者中,对外围动脉疾病的多种二次预防药物的不持续使用
Martin Wawruch1, Miriam Petrova1, Denisa Celovska2
1Institute of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Frontiers in pharmacology
|January 2, 2025
概括
患有外周动脉疾病 (PAD) 的高血压患者的二次预防需要始终坚持药物治疗. 这项研究确定了导致他类药物,抗血小板药物和抗高血压药物不持续使用的关键因素,突出了性别特异性差异,以改善患者的治疗结果.
科学领域:
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 患有外围动脉疾病 (PAD) 的高血压患者的二次预防依赖于持续使用他类药物,抗血小板药物和抗高血压药物 (ACEI / ARB).
- 不持续服用这些关键药物可能会损害有效的二次预防策略.
研究的目的:
- 分析新诊断PAD的高血压患者多种药物类别的不持续程度.
- 确定与这种患者队列中药物不持续性可能性相关的因素.
主要方法:
- 一项队列研究分析了3,401名高血压患者 (≥65岁) 在2012年新诊断患有PAD,接受了他类药物,抗血小板药物和ACEI/ARB治疗.
- 非持久性被定义为未能遵守至少三种药物类别中的至少一种.
- 考克斯回归被用来确定与非持久性概率相关的因素.
主要成果:
- 在平均1.8年的随访期间,55.0%的患者至少有一类药物不持久.
- 在整个队列中,与不持续性相关的因素包括女性性别,心房动和新药使用.
- 确定的性别特异性因素包括大学教育,男人的心房和,女人的新药使用.
结论:
- 在高血压PAD患者中,影响药物不持续性的因素存在显著的性别差异.
- 针对特定风险因素的有针对性的干预措施可以改善药物坚持.
- 加强组合治疗的持续性对于成功预防PAD的二次预防至关重要.
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