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Updated: Jun 4, 2025

A Flow Cytometry-based Assay for Measuring Mitochondrial Membrane Potential in Cardiac Myocytes After Hypoxia/Reoxygenation
07:14

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通过触发错误展开的蛋白质反应来利用线粒体,从而导致有效的心脏保护

Yang Shen1,2,3, Xin Gao4, Ying Xiang5

  • 1Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.

International journal of medical sciences
|January 2, 2025
PubMed
概括

Fundc1蛋白通过调节线粒体未折叠蛋白质响应 (mito-UPR) 途径和线粒体衰变来保护心脏免受高海拔低氧. 它的缺乏会使心脏功能障碍恶化,但激活米托-UPR或过度表达ATF5会恢复心脏功能.

关键词:
在ATF5中使用ATF5.FUNDC1 是一个基金.通过 mito-UPR 进行.线粒体. 线粒体.

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