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对EncephalAppStroop测试的外部验证,用于选非酒精性肝硬化症的肝脑病症最小患者

Ting-Ting Jiang¹, Xiao-Li Liu¹, Hao Yu¹

¹Center of Integrative Medicine, Beijing Ditan Hospital Affiliated to Capital Medical University, Beijing 100015, China.

World journal of hepatology

|January 2, 2025

概括

EncephalApp Stroop测试显示,在非酒精性肝硬化患者中查最小肝脑病变 (MHE) 是有前途的. 对于非酒精患者和酒精性肝硬化患者,建议使用不同的截止值,以确保准确的MHE诊断.

科学领域:

肝病学肝病学是一种肝病学.
神经科学是一个神经科学.
医疗技术医疗技术医学技术

背景情况:

神经认知障碍,包括最小的肝脑病变 (MHE),是肝脏疾病的常见并发症.
EncephalApp Stroop测试为MHE查提供了一种节省时间的方法.
由于酒精性肝硬化和非酒精性肝硬化之间的差异,现有的MHE诊断切线可能无法普遍适用.

研究的目的:

为了验证EncephalApp Stroop测试用于MHE查,特别是在非酒精性肝硬化患者中.
在这个群体中确定EncephalApp Stroop测试的适当切割值.

主要方法:

在160名非酒精性肝硬化患者中对EncephalApp Stroop测试的外部验证.
将EncephalApp Stroop测试结果与心理测量肝脏脑病率 (PHES) 评分作为黄金标准进行比较.
使用曲线下的面积 (AUC),灵敏度,特异性和预测值来评估测试性能.

主要成果:

在非酒精性肝硬化患者中,EncephalApp Stroop测试在"关闭"时间 (AUC:0.85) 和"开启+关闭"时间 (AUC:0.85) 上表现良好.
最佳切断点被确定为"关机"时间>101.93秒和"开启+关机"时间>205.86秒.
该测试在这些截止点实现了0.84-0.90的灵敏度和0.71-0.77的特异性.

结论:

EncephalApp Stroop测试是用于非酒精性肝硬化中MHE查的验证工具.
在非酒精患者和酒精性肝硬化患者中使用EncephalApp Stroop测试进行MHE查时,需要明确的切断值.
在所有慢性肝病患者广泛应用神经认知障碍查之前,这些发现至关重要.

关键词:

诊断诊断诊断诊断诊断 EncephalApp的Stroop测试是如何进行的最小的肝脏脑病变 - - 肝脏脑病变.没有酒精的肝硬化.查检查查检查查检查

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