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一个H2S激活的NIR-II成像探针用于精确诊断和结直肠瘤的病理评估

Yu Ji¹, Qinxian Huang², Qian Jia^1,3

¹Lab of Molecular Imaging and Translational Medicine (MITM), Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, School of Life Science and Technology, Xidian University & International Joint Research Center for Advanced Medical Imaging and Intelligent Diagnosis and Treatment, Xi'an, Shaanxi, 710126, P. R. China.

|January 2, 2025

概括

一个新的硫化 (H2S) 激活的探头,DCNP@PB,使结直肠癌 (CRC) 的精确可视化. 这种对H2S有反应的探针可以改善瘤检测,并有助于图像引导手术,以获得更好的患者结果.

科学领域:

生物医学成像技术生物医学成像技术
分子探头分子探头
癌症的诊断癌症的诊断

背景情况:

准确的结直肠癌 (CRC) 检测对于有效的治疗和生存至关重要.
目前对CRC的诊断方法往往缺乏足够的特异性和敏感性.
实时,准确的瘤划分仍然是CRC管理的一个重大挑战.

研究的目的:

开发一种新的探针,用于对结直肠癌 (CRC) 的具体可视化.
为了使图像引导的瘤手术使用强大的实时诊断解决方案.
创建一个内源硫化 (H2S) 激活的近红外II (NIR-II) 探测器,用于增强CRC检测.

主要方法:

使用聚烯酸介导的策略来合成DCNP@PB探头.
探测器的稳定性,生物相容性,H2S响应性和NIR-II成像能力在体外和体内进行了评估.
使用人类CRC组织和小鼠模型评估了探测器的性能.

主要成果:

该DCNP@PB探测器通过内部波效应 (IFE) 和光共振能量转移 (FRET) 在结直肠瘤中响应H2S的快速发光激活.
实现了高瘤到背景比率 (TBR),探针激活特异性与瘤部位内源H2S度相匹配.
该探测器在体内成功地区分了瘤和正常组织,并在人体组织样本中清楚地划出了癌症边界.

结论:

该研究提出了一个有前途的H2S激活的NIR-II光学探头 (DCNP@PB),用于静脉注射和体内应用.
开发的探头提供可靠的信息和快速反,用于精确的瘤诊断.
这项工作提供了一个有效的策略,用于设计可激活的成像探针,用于在癌症手术中进行手术内决策支持.

关键词:

在NIR-II成像系统中使用.结肠直肠癌是什么意思硫化是硫化的一种物质.分子探测器分子探测器瘤成像图像检查可以

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