Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Direct Motor Pathways01:11

Direct Motor Pathways

1.6K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
1.6K
Interference: Path Lengths01:10

Interference: Path Lengths

1.2K
Consider two sources of sound, that may or may not be in phase, emitting waves at a single frequency, and consider the frequencies to be the same.
Two special sources may be considered when they are in phase. This can be easily achieved by feeding the two sources from the same source. An example would be synchronizing the two speakers by feeding them with the same source, such as the sound waves produced by a tuning fork. This setup ensures that the two sources have the same frequency and are...
1.2K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

6.1K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.1K
Streamlines, Streaklines, and Pathlines01:18

Streamlines, Streaklines, and Pathlines

801
A streamline represents the trajectory that is always tangent to the fluid's velocity vector at any given point. The velocity of a fluid particle is always directed along the streamline, ensuring the particle continuously follows the streamline's path. Streamlines are particularly useful for visualizing the overall direction of flow in a fluid system, and they provide an instantaneous representation of the flow's velocity field. In steady flow, where conditions do not change over...
801
Divergence and Curl01:15

Divergence and Curl

1.6K
The divergence of a vector field at a point is the net outward flow of the flux out of a small volume through a closed surface enclosing the volume, as the volume tends to zero. More practically, divergence measures how much a vector field spreads out or diverges from a given point. For an outgoing flux, conventionally, the divergence is positive. The diverging point is often called the "source" of the field. Meanwhile, the negative divergence of a vector field at a point means that the...
1.6K
Path Between Thermodynamics States01:21

Path Between Thermodynamics States

2.9K
Consider the two thermodynamic processes involving an ideal gas that are represented by paths AC and ABC in Figure 1:
2.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Cross-System Transcriptomics Suggests Enterovirus A71 Exploits Wound Healing Programs to Target Neural Progenitors in Human Spinal Cord Organoids.

Infectious disorders drug targets·2026
Same author

Bioinformatics-based Investigation to Unveiling The miRNA-Immunity Axis in The Tumor Microenvironment of Pancreatic Cancer.

F1000Research·2026
Same author

Role of Dysregulated Immune Biomarkers in Hepatocellular Carcinoma Metastasis: A Systematic Meta-Analysis Review.

South Asian journal of cancer·2025
Same author

Long Noncoding RNAs (LncRNA-4.2, LncRNA-4.3) and Their Correlation With Hypoxia-Related Biomarkers in Breast Cancer.

The journal of gene medicine·2025
Same author

An <i>In silico</i> Multi-Omics Investigation of Alzheimer's Disease Linking Gene Dysregulation, Mutations, and Protein Networks to Core Pathologies.

Current Alzheimer research·2025
Same author

Transcriptomics Insights into Targeting CK2 Complex in <i>Cryptococcus neoformans</i>: Implications for Large-Scale Antifungal Virtual Screening.

Current medical mycology·2025

相关实验视频

Updated: May 7, 2025

Evaluation of an Exclusive Spur Dike U-Turn Design with Radar-Collected Data and Simulation
11:41

Evaluation of an Exclusive Spur Dike U-Turn Design with Radar-Collected Data and Simulation

Published on: February 1, 2020

20.2K

不同的路径:CAP59在Cryptococcus中的基因进化和对病原性的影响.

Noor Maath Ahmed1, Ahmed AbdulJabbar Suleiman2

  • 1Department of Biology, College of Science, Tikrit University, Tikrit, Saladin, Iraq.

Current medical mycology
|January 2, 2025
PubMed
概括

该研究发现了致病性和非致病性Cryptococcus物种之间的CAP59基因差异. 非致病性物种具有更长的CAP59序列,这表明潜在的进化途径致病性.

关键词:
生物信息学分析没有毒性的Cryptococcus.致病性 致病性 致病性有毒的加密球菌.CAP59 CAP59 是一个非常有价值的产品.加密球菌的毒性 加密球菌的毒性.

更多相关视频

Operation of the Collaborative Composite Manufacturing CCM System
10:09

Operation of the Collaborative Composite Manufacturing CCM System

Published on: October 1, 2019

6.5K
Quantifying Intermembrane Distances with Serial Image Dilations
07:45

Quantifying Intermembrane Distances with Serial Image Dilations

Published on: September 28, 2018

6.3K

相关实验视频

Last Updated: May 7, 2025

Evaluation of an Exclusive Spur Dike U-Turn Design with Radar-Collected Data and Simulation
11:41

Evaluation of an Exclusive Spur Dike U-Turn Design with Radar-Collected Data and Simulation

Published on: February 1, 2020

20.2K
Operation of the Collaborative Composite Manufacturing CCM System
10:09

Operation of the Collaborative Composite Manufacturing CCM System

Published on: October 1, 2019

6.5K
Quantifying Intermembrane Distances with Serial Image Dilations
07:45

Quantifying Intermembrane Distances with Serial Image Dilations

Published on: September 28, 2018

6.3K

科学领域:

  • 菌类学 菌类学是指菌类学.
  • 分子生物学分子生物学
  • 进化生物学 进化生物学

背景情况:

  • 新型菌 (Cryptococcus neoformans) 和菌 (Cryptococcus gattii) 是致命的真菌病原体,可引起严重的感染.
  • CAP59基因是这些致病物种中毒性的关键决定因素.

研究的目的:

  • 在致病性和非致病性Cryptococcus物种中研究CAP59基因.
  • 了解与CAP59相关的毒性分子基础.

主要方法:

  • 文献综述和从UniProt.prot. 的序列检索.
  • 生物信息分析包括InterPro,MEME,Clustal Omega,MEGA,MODELLER和PyMOL. 这三种类型的生物信息分析包括在内.
  • 对CAP59基因序列和蛋白质结构进行比较分析.

主要成果:

  • 在CAP59跨物种序列中确定了四个保护区.
  • 致病性CAP59序列较短,与非致病性序列相比,在保存区域中含有突变.
  • 遗传学分析表明Cryptococcus amylolentus与致病物种密切相关.

结论:

  • 非致病性Cryptococcus物种可能通过失去CAP59基因区域进化为致病性形式.
  • 这些发现表明了Cryptococcus毒性的潜在进化机制.
  • 对囊形成基因的进一步研究可以阐明这一进化过程.