制阻燃剂和牙周炎之间的关联:一项基于人口的大规模研究
Hao Jiang1, Jingwen Yin1, Meixiang Wang1
1The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, China.
Frontiers in public health
|January 2, 2025
概括
暴露于制阻燃剂 (BFRs) 与牙周炎的更高患病率有关. 这项研究发现BFRs与这种常见的牙疾病之间存在积极联系.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 牙周病学 牙周病学
背景情况:
- 制阻燃剂 (BFR) 和牙周炎之间的关系尚不清楚.
- BFR是广泛使用的化学物质,具有潜在的健康影响.
研究的目的:
- 调查BFR暴露与成人牙周炎患病率之间的关联.
- 探索潜在的剂量反应和非线性关系.
主要方法:
- 分析了2009-2014年NHANES周期中2,445名成年参与者的数据.
- 使用了调查加权的通用线性回归,受限立方线 (RCSs) 和量子量加权量子和 (WQS) 回归.
- 评估了血清BFR水平与牙周炎患病率之间的关联.
主要成果:
- 一些BFR成分,包括PBDE28,PBDE47,PBDE85,PBDE99,PBDE100,PBDE154和 PBB153,与牙周炎有积极的相关性.
- 随着PBDE28,PBDE85,PBDE100,PBDE154和 PBB153.3的四分位数较高,观察到牙周炎的几率增加.
- WQS和QGC分析证实了总体BFR暴露与牙周炎患病率之间存在显著的积极关联.
结论:
- 对BFR的总体暴露与牙周炎的患病率有关.
- 需要进一步的研究来阐明相关的因果关系和生物机制.
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