在青少年中,CLOCK基因多态与昼夜节律,时间营养,饮食摄入量和代谢参数之间的关联
Gizem Özata Uyar1, Hilal Yıldıran2, Demet Teker-Düztaş3
1Department of Nutrition and Dietetics, Kırıkkale University, Kırıkkale, Türkiye.
Frontiers in public health
|January 2, 2025
概括
钟基因中的遗传变异会影响青少年的肥胖风险和饮食习惯. 特定的CLOCK基因多态性与增加的BMI和改变的饮食模式有关,突出显示了时间营养在个性化营养策略中的作用.
科学领域:
- 遗传学 遗传学 是一个
- 时间生物学 时间生物学
- 营养科学 营养科学
背景情况:
- 循环发动机输出周期 Kaput (CLOCK) 基因变异与时间型,睡眠,肥胖和饮食摄入有关.
- 调查青少年的时间饮食习惯,一个时间营养的领域,是有限的.
- 了解基因饮食相互作用对于个性化营养至关重要.
研究的目的:
- 为了研究CLOCK基因多态 (rs3749474,rs4580704,rs1801260) 与生理节律,代谢参数和青少年的时间营养之间的关系.
- 探索CLOCK基因变异如何调节时间营养行为对BMIz-score的影响.
主要方法:
- 对300名青少年 (年龄11-18岁) 的横截面研究.
- 收集的人类测量,饮食摄入量,时间营养,昼夜,生化和生活方式数据.
- 分析的CLOCK基因多态 (rs3749474,rs4580704,rs1801260) 的结果.
主要成果:
- CLOCK rs3749474小T等位基因携带者有超重/肥胖的风险增加 (OR:2.106,p=0.003).
- CLOCK rs4580704小G等位基因携带者显示饮食能量摄入量增加和进食时差 (p<0.05).
- 在rs3749474和rs4580704携带者中,零食频率与BMI z分数相关;rs4580704 G基因基因基因与较低的早餐频率和BMI z分数相关;rs1801260 G基因基因基因基因基因与更高的餐饮频率和BMI z分数相关.
结论:
- 时钟基因的变异性部分调节了时间营养行为对青少年的BMIz分数的影响.
- 考虑到基因与饮食的相互作用,慢性营养对于个性化营养至关重要.
- 需要对更大,更多样化的群体进行未来的研究来证实这些发现.
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