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在儿科发病多发性硬化症中的真菌肠道微生物群

Nelson Mok¹, Natalie C Knox^1,2, Feng Zhu³

¹Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.

Frontiers in microbiology

|January 2, 2025

概括

这项研究揭示了儿科发病多发性硬化症 (POMS) 中明显的肠道真菌群落. 像Agaricus bisporus这样的特定真菌是丰富的,这表明了潜在的饮食联系,并突出了未来研究的罕见真菌标记.

科学领域:

微生物组研究微生物组研究
免疫学免疫学免疫学
神经学神经学

背景情况:

人们越来越认识到肠道微生物组在多发性硬化症 (MS) 中的作用,但研究主要集中在细菌上.
在儿科发病多发性硬化症 (POMS) 中的真菌微生物群 (mycobiota) 仍然在很大程度上未被探索.
了解POMS中的真菌生物组对于全面了解神经系统疾病中的肠道失生症至关重要.

研究的目的:

为了研究和比较患有POMS,获得的单相性脱髓化综合征 (monoADS) 和健康对照者的肠道菌群组成.
为了确定与POMS相关的特定真菌种群.
探索肠道菌群,饮食和POMS之间的潜在联系.

主要方法:

横截面研究分析了46名参与者的便样本 (18名POMS,13名MonoADS,15名对照).
在真菌内部转录的间隔器区域2 (ITS2) 的metataxonomic测序,以描述真菌生物组.
统计分析包括α和β多样性比较,后期测试和差异丰度预测建模.

主要成果:

在三个组中观察到肠道菌群α和β多样性的显著差异 (ANOVA,p < 0.05).
后期分析显示,单一ADS和POMS组之间存在明显的β多样性 (p=0.005调整).
在POMS参与者中,Agaricus属,特别是Agaricus bisporus非常丰富,这表明饮食的影响. 虫,Cyberlindera jadinii和Fusarium poae与POMS有很强的联系. 这些植物与POMS有很强的联系.

结论:

肠道真菌生物组的组成在有和没有POMS的个体之间有所不同.
饮食因素,例如食用 (Agaricus bisporus),可能会影响POMS中的肠道菌群.
罕见或未被检测到的真菌标志物在POMS中具有潜在的重要性,并且在未来的微生物组-MS研究中需要进一步调查.

关键词:

案例控制情况菌肠道微生物组的真菌在我的cobiota的肠道里单相性获得性脱髓化综合征多发性硬化症多发性硬化症儿科儿科儿科

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