在卵巢癌中TREM1的表达和预后价值:基于生物信息学和临床分析验证的综合研究
Caihong Tang1, Dong Ye2, Qiong He3
1Department of Urology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China.
Journal of Cancer
|January 2, 2025
概括
在卵巢癌中,肌肉细胞-1 (TREM1) 中表达的触发受体被上调,与生存率差相关. 这项研究确定TREM1是卵巢癌和其他癌症的潜在预后和免疫生物标志物.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 生物信息学是一种生物信息学.
背景情况:
- 在骨髓细胞-1 (TREM1) 中表达的触发受体放大了炎症反应,并调节了瘤微环境.
- 在卵巢癌 (OV) 中TREM1的特定作用尚未完全阐明.
- 了解TREM1的功能对于开发新的卵巢癌疗法至关重要.
研究的目的:
- 研究TREM1在卵巢癌中的表达特征和预后价值.
- 探索TREM1.1的生物功能和免疫调节作用.
- 为了验证TREM1作为潜在的胰腺癌生物标志物.
主要方法:
- 对TREM1表达和生存的TCGA和GEO数据库的生物信息分析.
- 卡普兰-梅尔,COX回归和诺莫格拉姆分析用于预后价值.
- 基因本体学 (GO),KEGG,基因组丰富分析 (GSEA),ESTIMATE和CIBERSORT用于功能和免疫相关性.
- 在临床样本上进行免疫组织化学 (IHC) 和RT-qPCR验证.
主要成果:
- 与正常组织相比,卵巢癌组织中TREM1的表达显著增加.
- 高TREM1表达与卵巢癌患者的整体存活率 (OS) 和无病存活率 (DFS) 较差有关.
- TREM1是卵巢癌的独立预后因素,与免疫细胞透相关,包括瘤相关巨细胞 (TAMs) 和调节性T细胞 (Tregs).
- 全癌症分析证实TREM1与各种癌症类型的预后和免疫基因表达的关联.
结论:
- 在卵巢癌中,TREM1 是一个有前途的预后生物标志物.
- 在卵巢癌的免疫微环境中,TREM1发挥着重要作用.
- TREM1显示出作为预后和免疫调节的泛癌生物标志物的潜力.
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