心血管健康与认知功能的关联以及抑郁状态的调解效应
Yiwei Hu1,2, Xuelu Sun1,2, Chen Guo1,2
1Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Frontiers in aging neuroscience
|January 2, 2025
概括
通过生活必需8 (LE8) 保持良好的心血管健康 (CVH) 与更好的认知功能有关. 抑郁症部分调解了这种关系,突出了对认知健康管理两者的重要性.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 公共卫生 公共卫生
背景情况:
- 有限的研究探讨了心血管健康 (CVH) 和认知功能之间的联系.
- 生活必需品8 (LE8) 是量化CVH的一个关键指标.
- 这项研究调查了LE8得分与认知功能之间的相关性,以及抑郁症的调解作用.
研究的目的:
- 探索心血管健康 (CVH) 与认知功能之间的潜在联系.
- 确定抑郁状态是否调解CVH和认知功能之间的关系.
- 通过生活方式干预来提供关于保持认知健康的见解.
主要方法:
- 利用了来自全国健康和营养检查调查 (NHANES) 的2,263名参与者的数据.
- 评估心血管健康 (CVH) 使用生活必需品8 (LE8) 评分.
- 通过动物流利性测试 (AFT),数字符号替代测试 (DSST) 和回忆测试评估认知功能;使用PHQ-9评估抑郁症.
主要成果:
- 在LE8分数和认知功能Z分数之间发现了显著的正线性关系.
- 在所有模型中,较高的LE8分数与认知功能正相关.
- 抑郁症被确定为CVH和认知功能之间的关系中的部分调解者.
结论:
- 更高的心血管健康与更好的认知功能有意义地相关.
- 抑郁症在心血管健康如何影响认知功能方面起着调解作用.
- 保持高CVH和管理抑郁症对于改善认知功能至关重要.
相关概念视频
Psychoneuroimmunology: Cardiovascular Disease
14
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
14
Assessment of the Cardiovascular System I: Subjective Data
235
A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
235
Stress and Mental Health
42
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
42
Ischemic Heart Disease: Overview
1.1K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.1K
Depressive Disorders: Etiology
17
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
17
Cognitive Development During Adulthood
21
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
21


