在口腔状细胞癌中的瘤微环境
Chenxi Li1, Xiaodan Dong1, Bo Li1
1Department of Oral Anatomy and Physiology, Jilin Provincial Key Laboratory of Oral Biomedical Engineering, Hospital of Stomatology, Jilin University, Changchun, China.
Frontiers in immunology
|January 2, 2025
概括
口腔状细胞癌 (OSCC) 的进展是由其瘤微环境 (TME) 驱动的. 本综述探讨了TME细胞如何相互作用以影响OSCC,为新的治疗策略提供了见解.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 免疫学 免疫学 免疫学
背景情况:
- 口腔状细胞癌 (OSCC) 是一种具有不良结果的侵袭性癌症.
- 目前治疗方法的局限性需要新的治疗方法.
- 瘤微环境 (TME) 显著影响OSCC的启动,发展和进展.
研究的目的:
- 审查当前关于TME中细胞组件在OSCC进展中的作用的文献.
- 阐明TME中各种细胞之间的复杂相互作用.
- 确定新型OSCC治疗策略的潜在目标.
主要方法:
- 对研究OSCC瘤微环境的综合文献综述.
- 分析关键细胞组件的作用,包括巨细胞,纤维细胞,淋巴细胞,中性粒细胞和树突细胞.
- 检查分子媒介物,如RNA,蛋白质,细胞因子和参与TME内的细胞-细胞通信的代谢物.
主要成果:
- TME包括多种细胞类型 (TAMs,CAFs,T细胞,TANs,MDSCs,DCs),形成一个关键网络.
- 这些细胞相互作用调节癌症的关键特征:扩散,入侵,迁移和血管生成.
- 分泌的分子 (RNA,蛋白质,细胞因子,代谢物) 介导TME细胞交叉通话的功能结果.
结论:
- 了解OSCC TME内部复杂的细胞网络对于推进诊断和治疗至关重要.
- 针对TME中复杂的细胞相互作用和通信通路,为新的治疗干预提供了有希望的途径.
- 这一审查为通过利用TME调制开发针对OSCC的创新策略提供了基础.
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