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揭开SARS-CoV-2尖端蛋白对神经PASC的长期影响

Filipe Menezes¹, Julys da Fonseca Palmeira², Juliana Dos Santos Oliveira²

¹Biotechnology Center, Instituto de Pesquisas Energéticas e Nucleares, IPEN-CNEN/SP, São Paulo, Brazil.

Frontiers in cellular neuroscience

|January 2, 2025

概括

长期的COVID,或COVID-19 (PASC) 后急性后续,可以导致神经问题 (神经-PASC). 由SARS-CoV-2尖端蛋白引起的血管功能障碍和血脑屏障破坏是拟议的机制.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
传染性疾病传染性疾病

背景情况:

长期COVID (COVID-19的后急性后果,PASC) 涉及影响多个系统的持续症状.
中枢神经系统 (CNS) 受到显著影响,导致神经症状 (神经PASC).
神经PASC的致病机制和风险因素尚未完全理解.

研究的目的:

审查和假设长期COVID/PASC.的病理生理机制.
专注于神经PASC的潜在原因.
探索SARS-CoV-2尖端蛋白在血脑界面中的作用.

主要方法:

文献综述和假设的制定.
讨论拟议的病理生理机制.
对尖蛋白和中枢神经系统组件之间的相互作用进行分析.

主要成果:

血管功能障碍,星细胞和细胞周细胞激活,以及血脑屏障 (BBB) 的破坏被认为是神经PASC的关键机制.
突出了SARS-CoV-2尖端蛋白在血液-大脑界面上的作用.
研究了涉及大脑中尖端蛋白与受体相互作用的潜在致病机制.

结论:

血管功能障碍和BBB干扰被假设为神经PASC的核心.
SARS-CoV-2 尖端蛋白可能在引发神经损伤方面发挥着关键作用.
需要进一步的研究来阐明神经PASC的精确机制.

关键词:

在SARS-CoV-2受体.在SARS-CoV-2病毒中,尖蛋白质是最常见的.血脑屏障血脑屏障血脑屏障血脑屏障神经PASC是一种神经PASC.病理生理学病理生理学

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