饮食维生素E摄入量与当前石块形成的关联:NHANES分析2017 - 2020年
Clinical nephrology
|January 2, 2025
概括
低饮食维生素E摄入量显著增加结石通过的几率. 这项人类研究支持动物研究表明,维生素E可以防止氧化酸结石形成.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 营养科学 营养科学
- 氧化压力生物学 氧化压力生物学
背景情况:
- 高氧化症诱导的氧化性管性损伤与氧酸盐结石形成有关.
- 维生素E是一种强有力的抗氧化剂,在老鼠模型中已证明有效防止氧酸盐晶体沉积.
- 研究饮食维生素E与人类结石病之间的关联至关重要.
研究的目的:
- 为了确定低饮食维生素E摄入量是否与人类结石发病率的增加有关.
- 评估维生素E摄入量与结石病之间的关系.
主要方法:
- 来自2017-2020年国家健康和营养检查调查数据的分析 (n=7,707).
- 使用多变量逻辑回归来评估维生素E摄入量 (≥15毫克/天) 与结石病之间的关联.
- 控制人口变量,水和营养摄入量 (,,维生素C) 和糖尿病.
主要成果:
- 结石病的总发病率为1.66%.
- 摄入<15毫克/天维生素E的个体的发病率较高 (1.8%),与摄入≥15毫克/天 (0.8%,p=0.024) 的人相比.
- 低维生素E摄入量与明显更高的石头通过率有关 (aOR = 2.83).
结论:
- 低饮食维生素E摄入量与患结石的几率增加了2.5倍以上.
- 这些发现与动物研究一致,表明维生素E在氧化石的病原发生过程中起着保护作用.
- 这是第一个将维生素E摄入与结石病联系起来的人类研究,需要对维生素E补充剂用于石头管理进行进一步的研究.
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