阿尔茨海默病的血生物标志物和身体功能在一个多样化的成年人样本
Gregory Knell1, James R Hall2,3, Stephanie Large2,4
1Department of Population & Community Health, College of Public Health, University of North Texas Health Science Center, Fort Worth, Texas, USA.
概括
更糟糕的身体功能与更高的阿尔茨海默病 (AD) 血生物标志物有关. 这些关联因种族和种族而异,突出显示了风险评估中需要多样化的数据的必要性.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 生物标志物研究 生物标志物研究
背景情况:
- 在不同的人群中,阿尔茨海默病 (AD) 血生物标志物与身体功能 (PF) 之间的联系尚不清楚.
- 在一个种族多样化的认知健康成年人群中研究这种关系对于理解神经退行性疾病风险至关重要.
研究的目的:
- 在多样化的社区成年人样本中探索AD血生物标志物和PF之间的关联.
- 检查种族和种族如何影响AD生物标志物与身体功能之间的关系.
主要方法:
- 对临床检查,神经心理测试,抽血和PF评估的分析 (定时升级和启动[TUG],短物理性能电池[SPPB]).
- 使用多变量线性回归来评估PF和AD等离子体生物标志物之间的关联,包括粉样蛋白β (Aβ) 40,Aβ42,总tau (t-tau) 和神经纤维光链 (NfL).
主要成果:
- 更糟糕的PF显著与更高水平的AD血生物标志物相关 (p <0.05).
- PF与生物标志物之间的关联在种族和种族群体之间存在差异.
- 像Aβ40,Aβ42和tau这样的特定生物标志物与非西班牙裔白人中的TUG时间有关,而t-tau和NfL与非裔美国人的SPPB分数有关.
结论:
- 身体功能,种族,种族和血AD生物标志物数据对于开发神经退行性疾病风险概况至关重要.
- 识别生物标志物和PF关联的种族差异对于准确的神经退行性疾病风险评估至关重要.
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