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相关概念视频

Proteomics01:33

Proteomics

7.0K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.0K

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Inhibition of BRD4 suppresses tumor growth in prostate cancer via the enhancement of FOXO1 expression.

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Fetal bovine serum promotes the development of in vitro porcine blastocysts by activating the Rho-associated kinase signalling pathway.

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Morphological, molecular, and electrophysiological aspects of skeletal muscle satellite cell-niche interactions: Focus on interstitial stromal non-myogenic cells.

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Age-related morphological and histological changes in the dromedary camel thymus.

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Isofraxidin ameliorates CCl<sub>4</sub>-induced liver fibrosis in mice by inhibiting the NF-κB pathway.

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FOXO3/HMOX1 axis promotes melanoma progression by regulating ferroptosis and immune escape.

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Immunohistochemical evaluation of CD44 expression and its correlation with clinicopathological factors and molecular markers (EGFR, STAT3, and lipid metabolism-related proteins) in oral squamous cell carcinoma.

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相关实验视频

Updated: May 7, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
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Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

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单细胞空间蛋白质组学

Senal Liyanage1, Jia Guo2

  • 1Biodesign Institute and School of Molecular Sciences, Arizona State University, Tempe, Arizona, USA.

Histology and histopathology
|January 2, 2025
PubMed
概括
此摘要是机器生成的。

单细胞空间蛋白质组学,使用质谱成像和多重免疫光学,揭示了细胞异质性和蛋白质功能. 这些技术促进了对生物系统的理解,用于诊断和个性化医疗.

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Proteome-wide Quantification of Labeling Homogeneity at the Single Molecule Level
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Single-Cell Proteomics Preparation for Mass Spectrometry Analysis Using Freeze-Heat Lysis and an Isobaric Carrier
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Single-Cell Proteomics Preparation for Mass Spectrometry Analysis Using Freeze-Heat Lysis and an Isobaric Carrier

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相关实验视频

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Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
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Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

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Proteome-wide Quantification of Labeling Homogeneity at the Single Molecule Level
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Proteome-wide Quantification of Labeling Homogeneity at the Single Molecule Level

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科学领域:

  • 蛋白质组学是指蛋白质组学.
  • 细胞生物学 细胞生物学
  • 生物技术是生物技术.

背景情况:

  • 单细胞空间蛋白质组学为细胞信号网络提供了新的见解.
  • 了解蛋白质的定位和功能对于健康和疾病研究至关重要.

研究的目的:

  • 审查单细胞空间蛋白质组学技术的进展.
  • 讨论这些方法的应用,挑战和未来方向.

主要方法:

  • 质谱 (MS) 成像用于高分辨率,高维的蛋白质概况.
  • 多复合免疫光 (mIF) 用于快速,高通量蛋白质分析.

主要成果:

  • 这些技术可以在单细胞水平上进行详细的蛋白质分析.
  • 空间蛋白质组学揭示了细胞异质性,组织和在本地环境中的功能.
  • 多发性硬化成像提供亚细胞定位和丰度数据;mIF提供速度和可访问性.

结论:

  • 空间蛋白质组学是理解复杂生物系统的强大工具.
  • 克服当前的方法挑战将提高它的实用性.
  • 与系统生物学的整合有望在诊断和个性化治疗方面取得进展.