高通量,通过连续喷的组合性滴滴生成
1Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York, USA. njc222@cornell.edu.
Lab on a chip
|January 2, 2025
概括
光编码溶液的连续喷射产生了用于高通量生物化学分析的组合滴. 这种新的方法通过量化随时间推移混合滴滴度,有效地分析抗生素相互作用.
科学领域:
- 生物化学 生物化学
- 生物技术是生物技术.
- 分析化学 分析化学
背景情况:
- 大量和微流体乳液方法提升了生物化学分析.
- 基于喷雾的技术提供了快速的滴滴生成,但由于随机的,多分散的滴滴,它们未得到充分利用.
研究的目的:
- 介绍一种基于喷雾的新方法,用于生成组合滴.
- 为了利用滴滴多分散性进行高通量生物化学分析.
- 通过使用这种新技术来研究双对抗生素相互作用.
主要方法:
- 连续喷的光编码的溶液.
- 混合液滴的生成以填充一个组合空间.
- 滴滴度的量化和随着时间的推移进行成像.
主要成果:
- 展示了一种创建可量化的度组合滴滴的方法.
- 成功地应用了该技术来研究抗生素相互作用.
- 展示了喷雾式方法对复杂的生物测试的实用性.
结论:
- 序列喷为高通量生物化学试验提供了一种可行的方法.
- 这种方法可以研究协同作用和对抗作用的相互作用.
- 利用滴滴多分散性扩大了喷雾式测试的能力.
相关概念视频
01:18Shotcrete
Shotcrete is a specialized technique where mortar or small aggregate concrete rich in cement content is sprayed onto a surface at high velocity. The force of impact compacts the material and enables it to cling to vertical or overhead areas without sagging. The technique involves layering the shotcrete in stages until it reaches approximately 4 inches in thickness. Operator skill in nozzle management is pivotal in deciding the quality of the shotcrete. Shotcrete is used in constructing tunnel...
01:28Pipe Flowrate Measurement: Problem Solving
A spray tank system is engineered to uniformly distribute a pest-control liquid across plants by using a pressurized mechanism. The tank, pressurized to 150 kPa, holds the pesticide at a height of 0.80 meters. Liquid flows from the tank through a 1.9 meter pipe with a diameter of 0.015 meters, angled at 0.698 radians, ultimately reaching a 0.007 meter nozzle that sprays the pesticide. Accurate calculation of the system's flow rate is crucial to ensure uniform application, and this is achieved...