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在诊断巨细胞激活的生物标志物
Dayne Voelker1, Thanai Pongdee
1Division of Allergic Diseases, Mayo Clinic Rochester, Rochester, Minnesota, USA.
Current opinion in allergy and clinical immunology
|January 2, 2025
概括
乳腺细胞激活诊断正在发展. 虽然血清三酶是标准的,但非侵入性尿细胞介质为识别细胞激活提供了一个有希望的,可访问的替代方案.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏和临床免疫学
- 生物化学 生物化学
背景情况:
- 巨细胞激活涉及由于各种刺激而释放化学介质.
- 目前用于诊断巨细胞激活的黄金标准依赖于症状发作期间的血清三酶水平.
研究的目的:
- 审查和突出生物标志物测量用于诊断巨细胞激活.
- 将已建立的生物标志物与新兴的非侵入性诊断工具进行比较.
主要方法:
- 对目前关于巨细胞激活生物标志物的文献的综述.
- 专注于血清三酶和尿细胞介导体.
主要成果:
- 血清三酶是最受欢迎的巨细胞激活的生物标志物.
- 尿液大细胞媒介物,包括N-甲基组胺,白血E4和2,3-dinor-11β-prostaglandin F2α,是新兴的非侵入性诊断工具.
- 尿媒可以在基线和症状恶化期间收集.
结论:
- 泌尿大细胞介质正在成为用于大细胞激活诊断的有价值的非侵入性生物标志物.
- 目前,试酶测量和尿杆细胞媒介体测量都是被接受的诊断生物标志物.
- 需要进一步的研究来识别和验证瘤细胞激活的新生物标志物.
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