可编程的食品衍生合组装策略,通过提高口服生物可用性和恢复肠道微环境平衡来促进向性结肠炎治疗
Meng Yang1,2, Jingbo Liu1, Chunmei Liu1
1Jilin Provincial Key Laboratory of Nutrition and Functional Food, College of Food Science and Engineering, Jilin University, Changchun 130062, China.
ACS nano
|January 2, 2025
概括
这项研究开发了使用食品衍生和黄素用于性结肠炎 (UC) 治疗的新型结肠向纳米颗粒,显著改善了营养递送和肠道健康. 这些纳米粒子增强了口服生物可用性,并有助于恢复肠道平衡,以有效治疗UC.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 胃肠病学 胃肠病学
背景情况:
- 性结肠炎 (UC) 治疗由于溶解性差和胃肠道过渡而面临口服营养药物输送的挑战.
- 现有的治疗方法往往缺乏有针对性的治疗,限制了疗效和患者的遵守.
研究的目的:
- 开发可控制的结肠向纳米颗粒 (NP) 来增强UC治疗中营养药的口服输送.
- 研究蛋白衍生 (EWDP) 与纳米颗粒的联合组装,以提高黄素 (Cur) 溶解度和治疗疗效.
主要方法:
- 使用四分位氨基基基托 (HTCC) 和酸修饰的γ-环极 (SACD) 核心制造NP,与EWDP和Cur.一起组装.
- 评估NP的合性质,pH敏感释放和细胞吸收.
- 评估体内口服生物可用性,粘液透,以及对肠道屏障和肠道微生物群的治疗作用.
主要成果:
- NP显示了增强的pH敏感的体化能力和高的营养药载荷能力.
- 与免费营养药相比,NP显著改善了细胞吸收 (10倍) 和口服生物可用性 (4-5倍).
- 有针对性的NP积累和顺序释放恢复了肠道屏障功能和肠道微生物群平衡,由EWDP联合组装效率调节.
结论:
- 开发的EWDP联合组装的NP为口服向性UC治疗提供了一个有希望的策略.
- 这种方法通过利用食品衍生的和纳米技术来增强营养药物输送,生物可用性和治疗结果.
- 使用EWDP的可编程纳米平台设计具有未来口腔向疗法的潜力.
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