对于养老院居民的重组与基于卵的四价流感疫苗接种:一个集群随机试验
Kevin W McConeghy1,2, H Edward Davidson3, David H Canaday4,5,6
1Transformative Health Systems Research to Improve Veteran Equity and Independence Center of Innovation, Veterans Affairs Providence Health Care System, Providence, Rhode Island.
JAMA network open
|January 2, 2025
概括
与标准疫苗相比,重组流感疫苗在养老院居民中并没有显著减少住院治疗. 由于COVID-19和疫苗匹配不佳等混因素,需要进一步研究.
科学领域:
- 老年学是一门学科.
- 疫苗学 疫苗学 疫苗学
- 传染性疾病 传染性疾病
背景情况:
- 流感疫苗接种对于预防养老院居民的疾病和死亡至关重要.
- 复合型流感疫苗的有效性在门诊患者中已知,但尚未在养老院群体中.
研究的目的:
- 为了比较用复合流感疫苗接种的养老院居民的住院率与标准剂量流感疫苗.
主要方法:
- 一个实用集群随机试验,涉及1078个养老院和超过144,000名居民.
- 养老院被分配给管理复合四价流感疫苗 (RIV4) 或标准的基于蛋的四价无活化流感疫苗 (IIV4).
- 使用Medicare索赔数据评估了居民级住院治疗结果.
主要成果:
- 在RIV4和IIV4组之间,与呼吸系统相关的住院病例没有显著差异 (1.9%对2.0%).
- 在两种疫苗组中,其他住院结果和死亡的比例也相似.
- 跨子组和季节的可比基线特征和结果.
结论:
- 再组合和标准剂量流感疫苗在减少养老院居民住院的情况方面没有显著差异.
- 结论受限于COVID-19大流行对流感活动的影响和疫苗菌株匹配不佳.
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