在奖励期望和躁狂风险期间的左腹侧前额叶皮层活动
Manan Arora1, Henry Chase1, Michele A Bertocci1
1Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
JAMA psychiatry
|January 2, 2025
概括
躁狂/低躁狂风险的神经标志物对于早期双相情感障碍 (BD) 诊断至关重要. 在奖励期望 (RE) 期间左腹侧前额皮层 (vlPFC) 活动升高与躁狂风险有关,但这种联系被严重抑郁症 (MDD) 史所削弱.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 躁狂/低躁狂是双相情感障碍 (BD) 的标志.
- 误诊BD作为主要抑郁障碍 (MDD) 是常见的,需要可靠的神经标志物用于早期诊断.
- 识别躁狂/低躁狂风险的神经相关性对于开发向治疗至关重要.
研究的目的:
- 复制左腹侧前额叶皮层 (vlPFC) 在奖励期望 (RE) 和躁狂/催眠症风险期间的活动之间的关联.
- 调查MDD史对这种关联的影响.
- 为了比较与RE相关的vlPFC活性在BD患者和BD风险人群中.
主要方法:
- 功能磁共振成像 (fMRI) 用于测量RE任务期间的大脑活动.
- 参与者包括具有不同精神病理的年轻成年人 (18-30岁),包括一个新样本,两个测试样本和患有euthymic BD.的个人.
- 在RE期间分析了左侧vlPFC中的活动,与躁狂/低躁狂风险得分和MDD史相关.
主要成果:
- 在RE期间的左侧vlPFC活动与样本中躁狂/催眠症风险之间发现了积极的关联.
- 在排除了有MDD病史的个体之后,这种关联仍然很重要.
- 与风险较低的群体相比,患躁狂/催眠狂的风险较高的个体和患有轻血性BD的个体表现出更高的RE相关的左侧vLPFC活性.
结论:
- 在RE期间左侧vlPFC活动升高是一种与躁狂/低躁狂风险相关的神经标志物.
- 患有MDD的病史可能会减弱这种神经关联.
- 这些发现凸显了左侧vlPFC作为针对躁狂/低躁狂或患有躁狂/低躁狂风险的个体的干预措施的潜在治疗目标.
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