非小细胞肺癌的成本效益模型:一个系统的文献审查
Michael Willis1, Andreas Nilsson1, Zin Min Thet Lwin1
1The Swedish Institute for Health Economics, Lund, Sweden (Willis, Nilsson, Thet Lwin, Brådvik).
Journal of managed care & specialty pharmacy
|January 2, 2025
概括
对非小细胞肺癌 (NSCLC) 的成本效益模型越来越多地开发,但许多人缺乏遵守报告标准. 提高模型质量和可访问性对于评估个性化NSCLC治疗至关重要.
科学领域:
- 卫生经济学 卫生经济学
- 在瘤学瘤学.
- 生物统计学 生物统计学
背景情况:
- 非小细胞肺癌 (NSCLC) 构成了全球健康的重大负担.
- 针对性疗法和免疫疗法的进步提供了个性化的治疗选择.
- 准确的成本效益分析对于评估NSCLC治疗,特别是个性化药物至关重要.
研究的目的:
- 确定和评估NSCLC的成本效益模型.
- 评估这些模型是否符合报告标准.
主要方法:
- 在PubMed和Embase (2012-2023) 的系统文献搜索.
- 从已识别的模型中提取和总结研究细节.
- 关于遵守"综合健康经济评估报告标准" (CHEERS) 的模型评估.
主要成果:
- 确定了237个独特的NSCLC成本效益模型,其中40%在2022-2023年发表.
- 大多数模型使用了标准的健康状态 (无进展生存,进展性疾病,死亡) 和时间到事件方程.
- 30个模型包含了用于生物标记指导治疗选择的诊断组件.
- 遵守CHEERS指南通常是不完整的,特别是对于特定模型的标准.
结论:
- NSCLC成本效益模型的扩散凸显了它们的重要性.
- 变量对最佳实践的坚持表明需要改善模型质量.
- 开发高质量的开源模型可以使研究人员受益,并加强NSCLC的成本效益分析.
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