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Updated: Jun 15, 2025

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游牧纳米药物:通过膜转移效应实现的药物

Krishna S Paranandi1,2, Eliz Amar-Lewis3,4,5, Chad A Mirkin1,6

  • 1International Institute for Nanotechnology, Northwestern University, Evanston, Illinois 60208, United States.

ACS nano
|January 2, 2025
PubMed
概括

纳米材料的细胞出口,或膜转移效应 (PTE),提供了新的治疗潜力. 纳米医学设计可以优化这种出口,以提高治疗结果.

关键词:
蜂出口出口蜂出口纳米医药是一种纳米医药.膜转移效应对膜的影响.球形核酸是球形核酸中的一种.

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Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
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Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
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