在激素受体阳性乳腺癌中辅助剂量密度化疗
Otto Metzger Filho1, Karla Ballman2, Jordan Campbell3
1Dana-Farber/Partners CancerCare, Harvard Medical School, Boston, MA.
概括
高剂量化疗为结节阳性乳腺癌患者提供了持续的长期益处. 对内分泌疗法的敏感性 (SET2,3) 测试确定了雌激素受体阳性患者,内分泌活性较低,从这种治疗中获益最多.
科学领域:
- 在瘤学瘤学.
- 翻译研究是翻译研究.
- 生物标志物开发 生物标志物开发
背景情况:
- 在节点阳性,雌激素受体阳性 (ER +) 乳腺癌中,化疗的益处有所不同.
- 对内分泌疗法的敏感性 (SET2,3) 测试测量了内分泌转录活性.
- 确定受益于特定化疗方案的患者至关重要.
研究的目的:
- 报告C9741试验的12年结果.
- 评估SET2,3测试预测剂量密集化疗效益的能力.
- 确定最有可能从剂量密集化疗中受益的患者子组.
主要方法:
- 1,973名患者被随机分配给剂量密集或常规化疗.
- 考克斯模型估计了无病生存期 (DFS) 和整体生存期 (OS) 的危险比率.
- 在682种ER+癌症的RNA样本上测试了SET2,3.
主要成果:
- 剂量密集化疗改善了DFS的23%和OS的20%整体.
- 在ER+和ER负子集中都观察到好处.
- 低SET2,3状态预测了剂量密集化疗的改善结果,表明受益于低内分泌活性.
结论:
- 辅助剂量密集化疗为结节阳性乳腺癌提供了持续的长期益处.
- 在SET2,3测试中确定了ER+乳腺癌患者,他们受益于剂量密集的化疗.
- 益处是由低内分泌活性预测的,而不是瘤负担,亚型或更年期状态.
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