成年人全因死亡率与阻塞性睡眠呼吸暂停之间的关联:U形曲线
Mehrnaz Azarian1,2, Amin Ramezani1,2, Amir Sharafkhaneh3,2
1Center for Innovations in Quality, Effectiveness, and Safety and.
Annals of the American Thoracic Society
|January 2, 2025
概括
睡眠呼吸暂停 (SA) 的严重程度显示了与死亡率的U形联系. 与轻度至中度SA相比,没有SA和严重SA都会增加全因死亡风险.
科学领域:
- 睡眠医学 睡眠医学
- 心血管健康 心血管健康
- 公共卫生 公共卫生
背景情况:
- 睡眠呼吸暂停 (SA) 和死亡率之间的关联是争论的.
- 了解SA严重程度对死亡率的影响对于患者的治疗结果至关重要.
研究的目的:
- 研究睡眠呼吸暂停严重程度与全因死亡率之间的关系.
- 为了检查年龄对睡眠呼吸暂停和死亡率之间的关联的影响.
主要方法:
- 开发了一个自然语言处理管道,从医生笔记中提取呼吸暂停-呼吸暂停指数 (AHI).
- 倾向匹配了179,121名参与者,分为无SA,轻度至中度SA和严重SA组.
- 使用后勤回归来分析全因死亡率,按年龄组分层.
主要成果:
- 死亡率呈现出AHI类别 (无SA,轻度至中度SA,严重SA) 的U形曲线.
- 没有SA的个人 (OR,1.72) 和严重的SA (OR,1.17) 与轻度至中度SA相比,所有原因死亡率的几率更高.
- 年龄分层显示了不同年龄组一致的U形死亡率模式.
结论:
- 所有原因的死亡率都显示出与呼吸暂停-呼吸暂停指数的U形关联.
- 需要进一步研究,以阐明睡眠呼吸暂停中观察到的U形死亡率模式背后的机制.
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