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Updated: Jun 4, 2025

High-throughput Screening for Protein-based Inheritance in S. cerevisiae
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High-throughput Screening for Protein-based Inheritance in S. cerevisiae

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使用马尔科夫状态模型,在子片段 (PrP127-132) 中对子129多态的结构性表征 (PrP127-132)

Wycliffe Omwansu1, Robinson Musembi1, Solomon Derese2

  • 1Department of Physics, Faculty of Science and Technology, University of Nairobi, P.O. Box 30197-00100, Nairobi, Kenya.

Journal of molecular graphics & modelling
|January 2, 2025
PubMed
概括

在PRNP代码子129的多态性影响病. 分子动力学模拟显示了 metionin (M129) 和 valine (V129) 变体之间的明显结构变化和稳定性差异,影响了疾病易感性.

关键词:
马尔科夫状态模型的模型.分子动力学模拟的模拟.PrP-M1299,这是一个很好的方法.这是PrP-V129的.这就是为什么PrP127-132是很重要的.

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