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在有症状的内动脉样硬化症患者中,CYP2C19多态的发生率

Songchai Kittipanprayoon¹, Pongpat Vorasayan², Aurauma Chutinet³

¹Department of Medicine, Hatyai Hospital, Songkhla, Thailand.

Cerebrovascular diseases extra

|January 2, 2025

概括

由于CYP2C19基因变异,近一半的泰国患有症状内狭窄症的患者是克洛皮多格雷尔代谢不良的. 这表明阿司匹林和克洛皮多格雷尔的联合治疗可能在这个人群中效果较差.

科学领域:

药物基因组学药物基因组学
神经学神经学
内部医学内部医学

背景情况:

克洛皮多格雷尔和阿司匹林对症状性内狭窄有益.
CYP2C19的遗传变异影响了克洛皮多格雷尔的疗效.
关于泰国患有这种疾病的患者中CYP2C19等位基因频率的数据有限.

研究的目的:

确定泰国患者中CYP2C19多态的流行率,这些患者有症状的内狭窄.

主要方法:

研究了一组100名泰国患者的队列,这些患者有症状的内狭窄.
使用实时聚合酶链反应 (rt-PCR) 进行了CYP2C19基因组 (*1, *2, *3, *17) 的基因定型.

主要成果:

这些等位基因的频率是:CYP2C19*1 (70.5%),CYP2C19*2 (26%),CYP2C19*3 (2.5%),以及CYP2C19*17 (1%).
53%的患者是正常代谢者,36%是中级代谢者,10%是低代谢者.

结论:

泰国患有症状内狭窄症的患者中很大一部分 (近50%) 是中等或低代谢者.
在这些患者中,阿司匹林和克洛皮多格雷尔联合治疗的有效性可能会受到损害.

关键词:

在CYP2C19的多态化中.克洛皮多格雷尔的使用方法缺血性中风是因为缺血性中风.有症状的内狭窄症.

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