中央自主网络连接的第三季度发展在子宫外环境中发生变化
Kelsey Christoffel1,2, Josepheen De Asis Cruz1, Kevin Michael Cook1
1Developing Brain Institute, Children's National Hospital, Washington, DC, USA.
Neonatology
|January 2, 2025
概括
中央自主网络 (CAN) 在早产婴儿和早产婴儿之间显示出不同的连接性,这会影响他们的发育. 这项研究将CAN连接性与早产婴儿的行为结果联系起来.
科学领域:
- 神经科学是一个神经科学.
- 发育儿科 发育儿科
- 自主神经系统研究 自主神经系统研究
背景情况:
- 中央自主网络 (CAN) 调节自主神经系统,并可能影响早产婴儿的心理社会和行为结果.
- 过早分娩与发育挑战的风险增加有关.
研究的目的:
- 为了比较健康的出生控制和早产婴儿之间的休息状态功能连接性.
- 调查CAN连接,月经后年龄 (PMA) 和早产婴儿行为结果之间的关系.
主要方法:
- 休息状态的功能性MRI被用于评估94名按期出生的婴儿和94名按期相当年龄的早产婴儿的CAN连接性.
- 在早产婴儿的CAN连接和PMA之间进行了相关性.
- 18个月的婴幼儿社会和情绪评估得分与早产队伍中CAN连接度相关.
主要成果:
- 与早产婴儿相比,预产婴儿在杏仁体,海马体,胰岛体,大脑干和丘脑中表现出明显更高的CAN连接.
- 在早产婴儿中,CAN连接与PMA在丘脑,胰岛,前,海马和杏仁体中具有积极的相关性.
- 在早产婴儿中,较高的岛内CAN连接与18个月的外化行为较少有关.
结论:
- 在早产新生儿中,CAN在第三个三个月内发展动态,与按期出生的新生儿不同,影响发育轨迹.
- 这项研究提供了使用静止状态fMRI在大量新生儿队列中首次描述CAN连接,并将其与行为结果联系起来.
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