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通过瓜尼迪诺,胺和胺的CESTMRI来阐明中风中的代谢物和pH值变化:在9.4T和3T进行的多领域比较研究

Kexin Wang¹, Licheng Ju², Guanda Qiao³

¹F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.

|January 2, 2025

概括

这项研究表明,guanidinoCEST和amineCEST的MRI对比可以有效地检测缺血性中风病变. 对于pH测绘,AmideCEST是最佳的,而amineCEST在高MRI场中检测反损伤.

科学领域:

生物医学成像技术生物医学成像技术
神经科学是一个神经科学.
医学物理医学物理

背景情况:

缺血性中风的诊断和监测严重依赖于先进的磁共振成像 (MRI) 技术.
化学交换和转移 (CEST) MRI提供了对分子环境敏感的新鲜对比机制.
了解中风模型中的CEST对比差异对于提高诊断准确性至关重要.

研究的目的:

在缺血性中风模型中研究guanidino (Guan),amine和amide的CEST对比.
为了比较高 (9.4T) 和临床 (3T) MRI场强度的CEST变化.
在中风病变中评估不同CEST对比的pH敏感性和B1依赖性.

主要方法:

在动物中使用了永久性 (pMCAO) 和暂时性 (tMCAO) 中脑动脉封闭模型.
应用了多项式和洛伦兹直线形状拟合 (PLOF) 方法来提取CEST对比度.
在9.4T和3T时检查了GuanCEST,amideCEST和amineCEST的B1依赖性和pH敏感性.

主要成果:

在9.4T (1.15-1.5%) 时,GuanCEST显示了中风病变的显著减少,表明pH敏感度高于amideCEST (0.5-0.62%).
在特定的B1范围内,AmineCEST在tMCAO模型 (3.85%) 和pMCAO模型 (0.87-1.0%) 中显示信号增加.
在较低的B1值下,amideCEST和GuanCEST将蛋白质和肌酸度绘制为独立于pH值的图.

结论:

关CEST和amineCEST对于划分中风病变非常敏感.
AmideCEST适用于精确的pH映射,不受代谢物变化的影响.
AmineCEST是一种敏感的MRI对比仪,用于检测高MRI场的反损伤.

关键词:

艾米德·塞斯特 (AmideCEST) 是一个氨基CEST (amineCEST) 是一种氨基基胺基.在阿根廷的CEST (ArgCEST)化学交换和转移 (CEST) 是一种蛋白质的质度 (CrCEST)创造蛋白映射创造蛋白映射瓜尼迪诺或瓜尼迪尼CEST (GuanCEST) 是一种永久的中脑动脉封闭 (pMCAO)多项式罗伦斯直线形拟合 (PLOF)再 perfusion 的意思是重新输注.一次性中风,中风.暂时的中脑动脉封闭 (tMCAO)绘制pH值的地图

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