多种药物连续释放系统:用于协同瘤治疗的构建和应用
Boyuan Yang1, Huijuan Liang1, Jiahao Xu1
1School of Life Science and Technology, Kunming University of Science and Technology, China.
International journal of pharmaceutics
|January 2, 2025
概括
多种药物连续释放系统 (MDSRS) 通过控制药物释放时间来优化癌症治疗. 本综述探讨了MDSRS设计,载体和用于改造瘤微环境以提高疗效的应用.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 在瘤学瘤学.
背景情况:
- 瘤治疗中的治疗效果受到药物使用顺序和时间的显著影响.
- 多种药物连续释放系统 (MDSRS) 提供了一种策略,用于控制,同时或连续输送多种治疗剂.
- 最近的进展侧重于通过精确定时的药物释放来协同治疗癌症.
研究的目的:
- 审查多药序列释放系统 (MDSRS) 的特性和设计原则.
- 总结用于MDSRS治疗癌症的载体结构.
- 突出MDSRS在调节瘤微环境 (TME) 和增强治疗结果中的应用.
主要方法:
- 对多种药物连续释放系统 (MDSRS) 现有文献的审查.
- 分析各种载体结构 (例如,核心外,层层,Janus,水凝).
- 检查具体示例,证明MDSRS在癌症治疗和TME调制中的应用.
主要成果:
- MDSRS表现出适合控制药物释放的多种特征和设计原则.
- 不同的载体架构促进了多种药物的连续递送.
- 通过多种机制,MDSRS在重塑瘤微环境 (TME) 和提高癌症治疗疗效方面表现有前途.
结论:
- 药物输送的顺序和时间对于有效的癌症治疗至关重要.
- 通过对药物释放进行精确控制,MDSRS代表了协同癌症治疗的宝贵平台.
- 对MDSRS局限性和挑战的进一步研究可以指导未来的药物开发,以改善癌症护理.
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