风险因素分析和名图,用于预测周期性基底细胞癌的复发
Xincen Hou1, Alexander C Rokohl2, Katharina Berndt1
1Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
概括
一种新的名图可以预测手术后基础细胞癌 (BCC) 复发. 关键因素包括年龄,病理,之前的BCC病史和手术数量,有助于个性化患者风险评估.
科学领域:
- 眼科医生 眼科 眼科
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
背景情况:
- 周周基细胞癌 (BCC) 在手术切除后存在局部复发的风险.
- 准确预测复发对于有效的患者管理和后续策略至关重要.
研究的目的:
- 开发和验证在经过手术治疗后患有周期性BCC的患者的无复发生存期 (RFS) 的预测性名谱.
主要方法:
- 对329名眼BCC患者进行了回顾性分析.
- 单变量和多变量考克斯回归确定了BCC复发的独立风险因素.
- 基于显著的风险因素构建了一个名图,以预测1年,2年和3年的RFS率.
主要成果:
- 在4.6%的患者 (329例中15例) 观察到局部复发.
- 复发的独立风险因素包括年龄,病理类型,以前的BCC病史和手术次数 (p < 0.05).
- 诺米图表显示出强大的预测准确性,C指数为0.867,AUC值从0.870到0.978.
结论:
- 年龄,病理类型,先前的BCC病史和手术史是周期性BCC复发的重要预测因素.
- 开发的诺莫图谱为准确预测个体患者复发风险和无复发生存率提供了宝贵的工具.
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