估计的脉冲波速度与外围动脉疾病之间的关系:基于NHANES的研究
Meiling Ning1, Xuehe Jiang1, Shuang Jia1
1Vascular Surgery Department, Qian Wei Hospital of Jilin Province, Changchun, China.
Vascular
|January 2, 2025
概括
估计的脉冲波速度 (ePWV) 有效地预测了外围动脉疾病 (PAD) 风险,特别是在老年人和BMI低于30的患者中. 较高的ePWV水平显著增加了PAD发病率.
科学领域:
- 心血管医学 心血管医学
- 血管生物学 血管生物学
- 流行病学 流行病学
背景情况:
- 周围动脉疾病 (PAD) 是导致残疾的重要原因,影响生活质量.
- 估计的脉冲波速度 (ePWV) 与动脉样硬化有关,但其与PAD的直接联系尚未得到充分证实.
研究的目的:
- 调查ePWV与发展PAD的风险之间的关系.
- 为了确定潜在的影响因素和ePWV和PAD之间的非线性关联.
主要方法:
- 对来自NHANES (1999-2004) 的6250名参与者的分析.
- 利用加权后勤回归,子组分析,值效应分析和受限立方线 (RCS) 模型.
- 探索非线性联系和影响因素.
主要成果:
- 在ePWV和PAD风险之间发现了显著的积极关联 (OR=1.29).
- 观察到一种非线性关系,当ePWV超过9.297.7时,PAD风险显著增加.
- 在60岁及以上的个体和BMI≤30.0的个体中,这种关联更为强烈.
结论:
- ePWV是对外围动脉疾病 (PAD) 风险的有价值预测指标.
- ePWV的预测价值在老年人和非肥胖人口中尤为明显.
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