经典的糖尿病酸性和euglycemic变体:一些旧的东西,一些新的东西
Adi E Mehta1, Robert Zimmerman2
1Department of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic, Cleveland, OH; Clinical Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH mehtaae@ccf.org.
Cleveland Clinic journal of medicine
|January 2, 2025
概括
糖尿病酸性酸症 (DKA) 可以发生在2型糖尿病中,特别是与SGLT-2抑制剂,导致euglycemic DKA. 管理涉及液体,电解质和胰岛素,含葡萄糖的液体对euglycemic DKA至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 药理学 药理学是指药理学的学科.
背景情况:
- 糖尿病酸性 (DKA) 传统上与1型糖尿病有关.
- 2型糖尿病患者可以患上DKA,通常与较不严重的酸性脂肪酸和较高的葡萄糖水平.
- -葡萄糖共运输体2 (SGLT-2) 抑制剂与一种特定的DKA变体有关:euglycemic DKA.
研究的目的:
- 描述euglycemic DKA的特征和管理.
- 要突出SGLT-2抑制剂在DKA呈现中的作用.
- 在2型糖尿病患者中概述DKA的治疗策略.
主要方法:
- 对DKA在2型糖尿病中的临床表现的综述.
- 分析SGLT-2抑制剂在葡萄糖和代谢中的机制.
- 讨论适用于euglycemic DKA的标准DKA管理原则.
主要成果:
- 由于其糖作用,SGLT-2 抑制剂可以诱导酸性,同时限制高血糖症.
- 优糖性DKA呈现出正常或接近正常的血糖水平.
- 管理euglycemic DKA需要及时使用含葡萄糖的IV液体来刺激胰岛素分泌并停止生成.
结论:
- 优糖性DKA是一种与SGLT-2抑制剂使用相关的已知的并发症.
- 延长SGLT-2抑制剂的作用可能会延长euglycemic DKA的持续时间.
- 标准的DKA管理原则适用于euglycemic DKA,强调葡萄糖的管理.
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