抗体的分子范围极为重要,这支着它们的病毒中和能力
Anna Huhn1, Daniel Nissley2, Daniel B Wilson1,3,4
1Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
Nature communications
|January 2, 2025
概括
抗体与病毒结合,如SARS-CoV-2,取决于分子范围,而不仅仅是亲和力. 这种新模型解释了为什么某些抗体比其他抗体更好地中和病毒,从而影响治疗性抗体设计.
科学领域:
- 免疫学 免疫学 免疫学
- 结构生物学 结构生物学
- 生物物理学的生物物理.
背景情况:
- 抗体功能,包括病毒中和,与高亲和度结合有关.
- 病毒中和和抗原亲和力之间的相关性仍然不太清楚.
研究的目的:
- 为了研究抗体结合特性与病毒中和功效之间的关系.
- 探索双价结合在抗体-抗原相互作用中的作用.
主要方法:
- 开发了一种双价抗体与抗原结合的机制模型.
- 研究了超过45个患者衍生的IgG1抗体与SARS-CoV-2 RBD结合.
- 分析了单价亲和力/动力学和双价参数,包括分子范围.
主要成果:
- 观察到抗体分子范围 (22-46 nm) 的显著变化,超过了抗体大小.
- 证明了抗体和抗原的大小都对分子范围有所贡献.
- 发现分子范围和病毒中和之间存在强烈的相关性,超过了亲和关系相关性.
结论:
- 分子范围,一种双价结合参数,是抗体中和有效性的关键决定因素.
- 抗体大小和抗原大小影响分子范围,调节结合和功能.
- 这一发现为抗体介导免疫和治疗性抗体开发提供了新的见解.
相关概念视频
Antibody Actions
1.1K
Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
1.1K
Affinity and Avidity
35.8K
Overview
35.8K
Immune Response Against Viral Pathogens
742
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
742
Antibody Structure
58.9K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
58.9K
Antibody Structure and Classes
766
Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
766
Humoral Immune Responses
71.3K
Overview
71.3K


