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Updated: May 11, 2026

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一个深度的多实例学习框架改善了微卫星不稳定性检测从瘤下一代测序

John Ziegler1,2, Jaclyn F Hechtman1,3, Satshil Rana1

  • 1Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Nature communications
|January 2, 2025
PubMed
概括

一个新的深度学习工具,MiMSI,准确地识别癌症基因组中的微卫星不稳定性 (MSI),即使瘤纯度低. 这提高了用于免疫检查点抑制剂治疗选择的生物标志物发现.

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相关概念视频

Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.