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妊娠期糖尿病会通过增加EZH2导致卵细胞的基因组过甲基化

Hong-Yan Guo1, Shou-Bin Tang1,2, Li-Jun Li1

  • 1College of Life Sciences, Institute of Reproductive Sciences, Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao Agricultural University, Qingdao, 266109, People's Republic of China.

Nature communications
|January 2, 2025
PubMed
概括

在母亲的孕期糖尿病 (GDM) 导致后代卵子细胞的DNA超甲基化,可能导致遗传代谢障碍. 这种表观遗传变化与增加的Ezh2表达有关,影响DNA甲基化模式.

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