在体外,原蛋白的抗炎活性及其对改善性结肠炎的影响
Xuan-Ying Xin1,2, Jing Zhou1, Gao-Ge Liu1
1College of Agriculture, Yabian University, Yanji, 133002, China.
NPJ science of food
|January 2, 2025
概括
来自鱼皮的原蛋白显示出显著的抗炎作用. 它们通过减少肠道炎症,恢复微生物平衡和加强肠道屏障,有效治疗性结肠炎.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病,治疗选择有限.
- 炎症和氧化应激在UC病变发生过程中起着关键作用.
- 肠道微生物群失调是UC的一个标志.
研究的目的:
- 评估来自皮的原蛋白的抗炎和治疗潜力.
- 研究原对炎症标记物,氧化应激和肠道屏障功能的影响,在体外和体内.
- 探索原对NF-κB/MAPK信号通路和肠道微生物群组成的影响.
主要方法:
- 在体外测试以评估抑制促炎性细胞因子和氧化应激.
- 使用性结肠炎动物模型进行体内研究.
- 对结肠组织损伤,血清细胞因子水平,紧结蛋白表达和肠道微生物群组成的分析.
- 西部斑点分析以调查NF-κB/MAPK信号通路.
主要成果:
- 原蛋白抑制了促炎性细胞因子分泌,并减少了氧化应激在体外.
- 在体内,原显著减少了结肠组织损伤,调节了血清细胞因子平衡.
- 治疗增加了紧结蛋白表达 (ZO-1,Occludin,Claudin-1),增强了有益的肠道细菌,并恢复了微生物平衡.
- 原抑制了NF-κB p65,IκBα和p38 MAPK的酸化,这表明NF-κB/MAPK通路的调节.
结论:
- 来自鱼皮的原具有显著的抗炎性质.
- 这些在性结肠炎模型中通过减少炎症,改善肠道屏障完整性和调节肠道微生物群来证明治疗效果.
- 原是一种有前途的天然治疗剂,用于治疗性结肠炎.
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