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Updated: Jun 4, 2025

Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons
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肝脏特异性基因PGRMC1通过ER压力独立的PERK激活阻断c-Myc诱导的肝癌发生

Fubo Ji1,2,3, Jianjuan Zhang1,2,3, Liping Mao1,2,3

  • 1The MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058, China.

Nature communications
|January 2, 2025
PubMed
概括

肝脏特异性基因 (LSGs) 在肝癌 (肝细胞癌,HCC) 中经常丢失. 减少PGRMC1,一个LSG,激活c-Myc通路,促进瘤生长和不良预后.

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