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Updated: Jun 4, 2025

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
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Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation

Published on: September 20, 2017

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抑制PIM2促进了血细胞中的MCL1依赖性,涉及综合应激反应驱动的NOXA表达

Marion Haas1,2, Sabrina Cherfa1, Léa Nguyen1,2

  • 1Université de Rennes 1, INSERM, Établissement Français du Sang de Bretagne, UMR_S1236, F-35043, Rennes, France.

Nature communications
|January 2, 2025
PubMed
概括

抑制癌细胞中的PIM2激酶激活了综合应激反应 (ISR),导致瘤细胞死亡. 联合PIM2和MCL1抑制显示出对攻击性癌症的治疗有希望.

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