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Updated: Jun 4, 2025

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通过真核胆-转移酶的脂合成的催化和选择性的结构基础

Jacquelyn R Roberts1,2, Yasuhiro Horibata3, Frank E Kwarcinski4

  • 1Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

Nature communications
|January 2, 2025
PubMed
概括

这项研究揭示了酵母CPT1的结构,详细介绍了在脂生物合成中对二甲基甘油 (DAG) 偏好和胆/乙醇胺选择性的关键残留物. 这些发现提出了CDP-酒精化酶 (CDP-APs) 的反应机制.

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